Pathologic Evaluation of Pig Kidney and Heart Xenografts: 2024 Recommendations from the Banff Xenotransplantation Pathology Working Group
Ivy Rosales et al
Read the full manuscript on SSRN
Abstract
The purpose of this white paper is to recommend the minimum reporting standards for pathologic characterization of kidney and heart xenografts in humans. This proposal is based on the current human classifications for kidney and heart allografts, with additions and caveats relevant to xenografts that are primarily based on non-human primate and a limited number of organ xenografts in decedent and living humans. Such recommendations should not be regarded as diagnostic criteria, given that many new pathologic patterns and mechanisms remain to be fully characterized. While xenograft transplantation continues to evolve, this report serves as groundwork and an initial step towards defining international standards in xenograft histopathology assessment and reporting.
Join the conversation by providing your comment(s) on the:
Clinical feasibility and utility of the classification
Areas of improvement for clarity and reduction of ambiguity
Inaccuracies and inconsistency
Evidence and knowledge gaps
The comment period will be open until August 31, 2025. All comments will be reviewed and considered by the Banff meeting report author groups prior to finalizing the manuscripts and submission for formal peer review.
How to comment:
Click on the comment box and you will be prompted to create an account
Once your account is created, you will return to the article, please enter your comment and click publish
Make sure to follow the post for updates on new comments and replies
Very nice paper - just for awareness, in light of the progress in Xeno transplantation, The Banff Foundation has adjusted its name from Banff Foundation for Allograft Pathology to Banff Foundation for Transplant Pathology to be inclusive of the emerging Xenotransplantation pathology community. Maybe the following sentence in the introduction can be modified to reflect this change?
"As the field makes a brisk step towards clinical application, the Banff Foundation for Allograft Pathology has established a Working Group for Xenotransplantation Pathology8 to initiate recommendations for xenograft tissue handling and evaluation, based on published literature and field expertise from experimental and preclinical work."
change to
As the field makes a brisk step towards clinical application, the Banff Foundation for Allograft Pathology has established a Working Group for Xenotransplantation Pathology8 to initiate recommendations for xenograft tissue handling and evaluation, based on published literature and field expertise from experimental and preclinical work. To be inclusive to this emerging field of pathology the Banff Foundation adjusted its name to the Banff Foundation for Transplant Pathology.
Also it might be helpful to add a few pictures of xeno specific pathology to the report? For example a photomicrograph of the unusual C4d staining patterns and/or the frequent TMAs, and examples of the proposed different glomerulitis scores.