XVIIth BANFF conference on Allograft pathology the BANFF workshop heart report: microvascular inflammatory burden in Heart Transplantation and the impact of non-invasive diagnostic tools.
M. Fedrigo et al
Full manuscript coming soon to SSRN
Abstract
The Banff-PITOR joint meeting on Allograft Pathology was held in 2024 in Paris. According to the BANFF policy, heart transplant group discussed two main topics: (a) the microvascular inflammatory burden on endomyocardial biopsy (EMB) exploring new advancements on inflammation-endothelium interactions within the complexity of inflammatory pathways on allograft, and (b) the impact of molecular non-invasive tools in the rejection monitoring. The goal was to discuss the impact of molecular pathology performed on paraffin-embedded tissue in the context of inflammatory burden on EMBs, to explore the new face of endothelium in the microvasculature and its relationship with alloantibodies. The introduction of tissue and blood molecular analysis enhanced the reliability and accuracy of EMBs interpretation by pathologists and also emphasized the complexity of the inflammatory mechanisms occurring in the allograft. The excellent negative predictive value of non-invasive biomarkers and the new imaging modalities foresee the applicability in the clinical practice and potentially changing the follow up of the heart transplanted patients.
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