Elizabeth N. Pavlisko et al
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Abstract
The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference - held in Banff, Alberta - focused on non-rejection lung allograft pathology and novel technologies for the detection and of allograft injury. A multidisciplinary approach focused on current histopathologic entities, serologic and molecular practices, as well as novel applications including artificial intelligence, gene expression analysis, and quantitative image analysis of chest computerized tomography. Prospective integration of these technologies for complete assessment of graft injury and the potential impact on lung transplant outcomes was discussed. Key conclusions were 1) recognition of limitations in current standard of care assessment of lung allograft dysfunction 2) agreement on the need for a standardized approach to the collection and assessment of pathological data, inclusive of all lesions associated with graft outcome, and 3) optimism regarding the potential for emerging technologies to direct personalized therapies to improve graft outcomes.
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